Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading

Cell spreading requires the coupling of actin-driven membrane protrusion and integrin-mediated adhesion to the extracellular matrix. The integrin-activating adaptor protein kindlin-2 plays a central role for cell adhesion and membrane protrusion by directly binding and recruiting paxillin to nascent...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Böttcher, Ralph T., Veelders, Maik, Rombaut, Pascaline, Faix, Jan, Theodosiou, Marina, Stradal, Theresa E., Rottner, Klemens, Zent, Roy, Herzog, Franz, Fässler, Reinhard
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5674885/
https://ncbi.nlm.nih.gov/pubmed/28912124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201701176
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