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Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin
Integrins require an activation step prior to ligand binding and signaling. How talin and kindlin contribute to these events in non-hematopoietic cells is poorly understood. Here we report that fibroblasts lacking either talin or kindlin failed to activate β1 integrins, adhere to fibronectin (FN) or...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4749545/ https://ncbi.nlm.nih.gov/pubmed/26821125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10130 |
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