Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin

Integrins require an activation step prior to ligand binding and signaling. How talin and kindlin contribute to these events in non-hematopoietic cells is poorly understood. Here we report that fibroblasts lacking either talin or kindlin failed to activate β1 integrins, adhere to fibronectin (FN) or...

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Dettagli Bibliografici
Pubblicato in:eLife
Autori principali: Theodosiou, Marina, Widmaier, Moritz, Böttcher, Ralph T, Rognoni, Emanuel, Veelders, Maik, Bharadwaj, Mitasha, Lambacher, Armin, Austen, Katharina, Müller, Daniel J, Zent, Roy, Fässler, Reinhard
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2016
Soggetti:
Biochemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749545/
https://ncbi.nlm.nih.gov/pubmed/26821125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10130
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