Cryo-EM structure of human DNA-PK holoenzyme

DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein kinase complex composed of a catalytic subunit (DNA-PKcs) and KU70/80 heterodimer bound to DNA. DNA-PK holoenzyme plays a critical role in non-homologous end joining (NHEJ), the major DNA repair pathway. Here, we determined cryo-ele...

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Publicat a:Cell Res
Autors principals: Yin, Xiaotong, Liu, Mengjie, Tian, Yuan, Wang, Jiawei, Xu, Yanhui
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5674154/
https://ncbi.nlm.nih.gov/pubmed/28840859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.110
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