Novel ATP‐competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells

Malignant pleural mesothelioma (MPM), an asbestos‐related occupational disease, is an aggressive and incurable tumor of the thoracic cavity. Despite recent advances in MPM treatment, overall survival of patients with MPM is very low. Recent studies have implicated that PI3K/Akt signaling is involved...

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Vydáno v:Cancer Med
Hlavní autoři: Yamaji, Masayuki, Ota, Akinobu, Wahiduzzaman, Md, Karnan, Sivasundaram, Hyodo, Toshinori, Konishi, Hiroyuki, Tsuzuki, Shinobu, Hosokawa, Yoshitaka, Haniuda, Masayuki
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Cancer Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673922/
https://ncbi.nlm.nih.gov/pubmed/28960945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1179
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