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A human bi-specific antibody against Zika virus with high therapeutic potential

Zika virus (ZIKV), a mosquito-borne flavivirus, causes devastating congenital birth defects. We isolated a human monoclonal antibody (mAb), ZKA190, that potently cross-neutralizes multi-lineage ZIKV strains. ZKA190 is highly effective in vivo in preventing morbidity and mortality of ZIKV-infected mi...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Wang, Jiaqi, Bardelli, Marco, Espinosa, Diego A., Pedotti, Mattia, Ng, Thiam-Seng, Bianchi, Siro, Simonelli, Luca, Lim, Elisa X.Y., Foglierini, Mathilde, Zatta, Fabrizia, Jaconi, Stefano, Beltramello, Martina, Cameroni, Elisabetta, Fibriansah, Guntur, Shi, Jian, Barca, Taylor, Pagani, Isabel, Rubio, Alicia, Broccoli, Vania, Vicenzi, Elisa, Graham, Victoria, Pullan, Steven, Dowall, Stuart, Hewson, Roger, Jurt, Simon, Zerbe, Oliver, Stettler, Karin, Lanzavecchia, Antonio, Sallusto, Federica, Cavalli, Andrea, Harris, Eva, Lok, Shee-Mei, Varani, Luca, Corti, Davide
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673489/
https://ncbi.nlm.nih.gov/pubmed/28938115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.002
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