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Rational Engineering of a Human Anti-Dengue Antibody through Experimentally Validated Computational Docking

Antibodies play an increasing pivotal role in both basic research and the biopharmaceutical sector, therefore technology for characterizing and improving their properties through rational engineering is desirable. This is a difficult task thought to require high-resolution x-ray structures, which ar...

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Detalhes bibliográficos
Main Authors: Simonelli, Luca, Pedotti, Mattia, Beltramello, Martina, Livoti, Elsa, Calzolai, Luigi, Sallusto, Federica, Lanzavecchia, Antonio, Varani, Luca
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566030/
https://ncbi.nlm.nih.gov/pubmed/23405171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055561
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