Specific mutations in the D1–D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors

Valosin-containing protein (VCP), together with several partner proteins, extracts ubiquitinated client proteins from E3 ligase complex and facilitates their degradation through ubiquitin–proteasome system. Therefore, it plays an important role in regulating protein quality control and various cellu...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Discov
Egile Nagusiak: Bastola, Prabhakar, Wang, Feng, Schaich, Matthew A, Gan, Taiping, Freudenthal, Bret D, Chou, Tsui-Fen, Chien, Jeremy
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672561/
https://ncbi.nlm.nih.gov/pubmed/29367883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2017.65
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