Specific mutations in the D1–D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors

Valosin-containing protein (VCP), together with several partner proteins, extracts ubiquitinated client proteins from E3 ligase complex and facilitates their degradation through ubiquitin–proteasome system. Therefore, it plays an important role in regulating protein quality control and various cellu...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell Death Discov
Päätekijät: Bastola, Prabhakar, Wang, Feng, Schaich, Matthew A, Gan, Taiping, Freudenthal, Bret D, Chou, Tsui-Fen, Chien, Jeremy
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672561/
https://ncbi.nlm.nih.gov/pubmed/29367883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2017.65
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