Specific mutations in the D1–D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors

Valosin-containing protein (VCP), together with several partner proteins, extracts ubiquitinated client proteins from E3 ligase complex and facilitates their degradation through ubiquitin–proteasome system. Therefore, it plays an important role in regulating protein quality control and various cellu...

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Detaylı Bibliyografya
Yayımlandı:Cell Death Discov
Asıl Yazarlar: Bastola, Prabhakar, Wang, Feng, Schaich, Matthew A, Gan, Taiping, Freudenthal, Bret D, Chou, Tsui-Fen, Chien, Jeremy
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672561/
https://ncbi.nlm.nih.gov/pubmed/29367883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2017.65
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