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Role of the D1-D2 Linker of Human VCP/p97 in the Asymmetry and ATPase Activity of the D1-domain

Human AAA(+) protein p97 consists of an N-domain and two tandem ATPase domains D1 and D2, which are connected by the N-D1 and the D1-D2 linkers. Inclusion of the D1-D2 linker, a 22-amino acid peptide, at the end of p97 N-D1 truncate has been shown to activate ATP hydrolysis of its D1-domain, althoug...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Tang, Wai Kwan, Xia, Di
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4730245/
https://ncbi.nlm.nih.gov/pubmed/26818443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20037
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