Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis

OBJECTIVE—: The cellular demand for cholesterol requires control of its biosynthesis by the mevalonate pathway. Regulation of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase), a rate-limiting enzyme in this pathway and the target of statins, is a key control point herein. Accordingly, HMGCR i...

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Vydáno v:Arterioscler Thromb Vasc Biol
Hlavní autoři: Loregger, Anke, Raaben, Matthijs, Tan, Josephine, Scheij, Saskia, Moeton, Martina, van den Berg, Marlene, Gelberg-Etel, Hila, Stickel, Elmer, Roitelman, Joseph, Brummelkamp, Thijn, Zelcer, Noam
Médium: Artigo
Jazyk:Inglês
Vydáno: Lippincott Williams & Wilkins 2017
Témata:
Basic Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5671778/
https://ncbi.nlm.nih.gov/pubmed/28882874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.310002
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