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Inhibition of PI3K/Akt/mTOR overcomes cisplatin resistance in the triple negative breast cancer cell line HCC38

BACKGROUND: Widely established targeted therapies directed at triple negative breast cancer (TNBC) are missing. Classical chemotherapy remains the systemic treatment option. Cisplatin has been tested in TNBC but bears the disadvantage of resistance development. The purpose of this study was to ident...

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Опубликовано в: :BMC Cancer
Главные авторы: Gohr, Katharina, Hamacher, Alexandra, Engelke, Laura H., Kassack, Matthias U.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5670521/
https://ncbi.nlm.nih.gov/pubmed/29100507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3695-5
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