Inhibition of discoidin domain receptor 1 reduces collagen-mediated tumorigenicity in pancreatic ductal adenocarcinoma

The extracellular matrix (ECM), a principal component of pancreatic ductal adenocarcinoma (PDA), is rich in fibrillar collagens that facilitate tumor cell survival and chemoresistance. Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that specifically binds fibrillar collagens and ha...

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Detaylı Bibliyografya
Yayımlandı:Mol Cancer Ther
Asıl Yazarlar: Aguilera, Kristina Y., Huang, Huocong, Du, Wenting, Hagopian, Moriah M., Wang, Zhen, Hinz, Stefan, Hwang, Tae Hyun, Wang, Huamin, Fleming, Jason B., Castrillon, Diego H., Ren, Xiaomei, Ding, Ke, Brekken, Rolf A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669827/
https://ncbi.nlm.nih.gov/pubmed/28864681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0834
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