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Inhibition of discoidin domain receptor 1 reduces collagen-mediated tumorigenicity in pancreatic ductal adenocarcinoma

The extracellular matrix (ECM), a principal component of pancreatic ductal adenocarcinoma (PDA), is rich in fibrillar collagens that facilitate tumor cell survival and chemoresistance. Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that specifically binds fibrillar collagens and ha...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Aguilera, Kristina Y., Huang, Huocong, Du, Wenting, Hagopian, Moriah M., Wang, Zhen, Hinz, Stefan, Hwang, Tae Hyun, Wang, Huamin, Fleming, Jason B., Castrillon, Diego H., Ren, Xiaomei, Ding, Ke, Brekken, Rolf A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669827/
https://ncbi.nlm.nih.gov/pubmed/28864681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0834
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