Overcoming CD4 Th1 cell fate restrictions to sustain antiviral CD8 T cells and control persistent virus infection

Viral persistence specifically inhibits CD4 Th1 responses and promotes Tfh immunity, yet the mechanisms that suppress Th1 cells and the disease consequences of their loss are unclear. We demonstrate that the loss of CD4 Th1 cells specifically leads to the progressive CD8 T cell decline and dysfuncti...

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Pubblicato in:Cell Rep
Autori principali: Snell, Laura M., Osokine, Ivan, Yamada, Douglas H., De la Fuente, Justin Rafael, Elsaesser, Heidi J., Brooks, David G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669380/
https://ncbi.nlm.nih.gov/pubmed/27653690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.065
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