Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence

Persistent viral infections are simultaneously associated with chronic inflammation and highly potent immunosuppressive programs mediated by IL-10 and PDL1 that attenuate antiviral T cell responses. Inhibiting these suppressive signals enhances T cell function to control persistent infection; yet, t...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Cunningham, Cameron R., Champhekar, Ameya, Tullius, Michael V., Dillon, Barbara Jane, Zhen, Anjie, de la Fuente, Justin Rafael, Herskovitz, Jonathan, Elsaesser, Heidi, Snell, Laura M., Wilson, Elizabeth B., de la Torre, Juan Carlos, Kitchen, Scott G., Horwitz, Marcus A., Bensinger, Steven J., Smale, Stephen T., Brooks, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726812/
https://ncbi.nlm.nih.gov/pubmed/26808628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005356
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