High-throughput single-molecule telomere characterization

We have developed a novel method that enables global subtelomere and haplotype-resolved analysis of telomere lengths at the single-molecule level. An in vitro CRISPR/Cas9 RNA-directed nickase system directs the specific labeling of human (TTAGGG)n DNA tracts in genomes that have also been barcoded u...

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Detaylı Bibliyografya
Yayımlandı:Genome Res
Asıl Yazarlar: McCaffrey, Jennifer, Young, Eleanor, Lassahn, Katy, Sibert, Justin, Pastor, Steven, Riethman, Harold, Xiao, Ming
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2017
Konular:
Method
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668947/
https://ncbi.nlm.nih.gov/pubmed/29025896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.222422.117
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