High-throughput single-molecule telomere characterization

We have developed a novel method that enables global subtelomere and haplotype-resolved analysis of telomere lengths at the single-molecule level. An in vitro CRISPR/Cas9 RNA-directed nickase system directs the specific labeling of human (TTAGGG)n DNA tracts in genomes that have also been barcoded u...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genome Res
Prif Awduron: McCaffrey, Jennifer, Young, Eleanor, Lassahn, Katy, Sibert, Justin, Pastor, Steven, Riethman, Harold, Xiao, Ming
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2017
Pynciau:
Method
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668947/
https://ncbi.nlm.nih.gov/pubmed/29025896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.222422.117
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