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High-throughput single-molecule telomere characterization
We have developed a novel method that enables global subtelomere and haplotype-resolved analysis of telomere lengths at the single-molecule level. An in vitro CRISPR/Cas9 RNA-directed nickase system directs the specific labeling of human (TTAGGG)n DNA tracts in genomes that have also been barcoded u...
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| Publicado no: | Genome Res |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5668947/ https://ncbi.nlm.nih.gov/pubmed/29025896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.222422.117 |
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