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RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
Although ubiquitin ligases have been implicated in autism, their roles and mechanisms in brain development remain incompletely understood. Here, we report that in vivo knockdown or conditional knockout of the autism-linked ubiquitin ligase RNF8 or associated ubiquitin-conjugating enzyme UBC13 in rod...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5668370/ https://ncbi.nlm.nih.gov/pubmed/29097665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01333-6 |
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