RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain

Although ubiquitin ligases have been implicated in autism, their roles and mechanisms in brain development remain incompletely understood. Here, we report that in vivo knockdown or conditional knockout of the autism-linked ubiquitin ligase RNF8 or associated ubiquitin-conjugating enzyme UBC13 in rod...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Valnegri, Pamela, Huang, Ju, Yamada, Tomoko, Yang, Yue, Mejia, Luis A., Cho, Ha Y., Oldenborg, Anna, Bonni, Azad
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668370/
https://ncbi.nlm.nih.gov/pubmed/29097665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01333-6
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