RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain

Although ubiquitin ligases have been implicated in autism, their roles and mechanisms in brain development remain incompletely understood. Here, we report that in vivo knockdown or conditional knockout of the autism-linked ubiquitin ligase RNF8 or associated ubiquitin-conjugating enzyme UBC13 in rod...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Valnegri, Pamela, Huang, Ju, Yamada, Tomoko, Yang, Yue, Mejia, Luis A., Cho, Ha Y., Oldenborg, Anna, Bonni, Azad
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668370/
https://ncbi.nlm.nih.gov/pubmed/29097665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01333-6
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