Oral administration of pyrophosphate inhibits connective tissue calcification

Various disorders including pseudoxanthoma elasticum (PXE) and generalized arterial calcification of infancy (GACI), which are caused by inactivating mutations in ABCC6 and ENPP1, respectively, present with extensive tissue calcification due to reduced plasma pyrophosphate (PPi). However, it has alw...

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Gepubliceerd in:EMBO Mol Med
Hoofdauteurs: Dedinszki, Dóra, Szeri, Flóra, Kozák, Eszter, Pomozi, Viola, Tőkési, Natália, Mezei, Tamás Róbert, Merczel, Kinga, Letavernier, Emmanuel, Tang, Ellie, Le Saux, Olivier, Arányi, Tamás, van de Wetering, Koen, Váradi, András
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666306/
https://ncbi.nlm.nih.gov/pubmed/28701330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201707532
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