Functional rescue of ABCC6 deficiency by 4-phenylbutyrate therapy reduces dystrophic calcification in Abcc6(−/−) mice

Soft tissue calcification is associated with aging, common conditions such as diabetes or hypercholesterolemia and with certain genetic disorders. ABCC6 is an efflux transporter primarily expressed in liver facilitating the release of ATP from hepatocytes. Within the liver vasculature, ATP is conver...

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Dades bibliogràfiques
Publicat a:J Invest Dermatol
Autors principals: Pomozi, Viola, Brampton, Christopher, Szeri, Flóra, Dedinszki, Dóra, Kozák, Eszter, van de Wetering, Koen, Hopkins, Hi’ilani, Martin, Ludovic, Váradi, András, Le Saux, Olivier
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5326614/
https://ncbi.nlm.nih.gov/pubmed/27826008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2016.10.035
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