Functional rescue of ABCC6 deficiency by 4-phenylbutyrate therapy reduces dystrophic calcification in Abcc6(−/−) mice

Soft tissue calcification is associated with aging, common conditions such as diabetes or hypercholesterolemia and with certain genetic disorders. ABCC6 is an efflux transporter primarily expressed in liver facilitating the release of ATP from hepatocytes. Within the liver vasculature, ATP is conver...

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Detalhes bibliográficos
Publicado no:J Invest Dermatol
Main Authors: Pomozi, Viola, Brampton, Christopher, Szeri, Flóra, Dedinszki, Dóra, Kozák, Eszter, van de Wetering, Koen, Hopkins, Hi’ilani, Martin, Ludovic, Váradi, András, Le Saux, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5326614/
https://ncbi.nlm.nih.gov/pubmed/27826008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2016.10.035
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