Functional rescue of ABCC6 deficiency by 4-phenylbutyrate therapy reduces dystrophic calcification in Abcc6(−/−) mice

Soft tissue calcification is associated with aging, common conditions such as diabetes or hypercholesterolemia and with certain genetic disorders. ABCC6 is an efflux transporter primarily expressed in liver facilitating the release of ATP from hepatocytes. Within the liver vasculature, ATP is conver...

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Bibliografische gegevens
Gepubliceerd in:J Invest Dermatol
Hoofdauteurs: Pomozi, Viola, Brampton, Christopher, Szeri, Flóra, Dedinszki, Dóra, Kozák, Eszter, van de Wetering, Koen, Hopkins, Hi’ilani, Martin, Ludovic, Váradi, András, Le Saux, Olivier
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5326614/
https://ncbi.nlm.nih.gov/pubmed/27826008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2016.10.035
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