Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in Pseudomonas aeruginosa

While much attention has been focused on acquired antibiotic resistance genes, chromosomal mutations may be most important in chronic infections where isolated, persistently infecting lineages experience repeated antibiotic exposure. Here, we used experimental evolution and whole-genome sequencing t...

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Vydáno v:mBio
Hlavní autoři: Jorth, Peter, McLean, Kathryn, Ratjen, Anina, Secor, Patrick R., Bautista, Gilbert E., Ravishankar, Sumedha, Rezayat, Amir, Garudathri, Jayanthi, Harrison, Joe J., Harwood, Rachel A., Penewit, Kelsi, Waalkes, Adam, Singh, Pradeep K., Salipante, Stephen J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666152/
https://ncbi.nlm.nih.gov/pubmed/29089424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00517-17
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