Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in Pseudomonas aeruginosa

While much attention has been focused on acquired antibiotic resistance genes, chromosomal mutations may be most important in chronic infections where isolated, persistently infecting lineages experience repeated antibiotic exposure. Here, we used experimental evolution and whole-genome sequencing t...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Jorth, Peter, McLean, Kathryn, Ratjen, Anina, Secor, Patrick R., Bautista, Gilbert E., Ravishankar, Sumedha, Rezayat, Amir, Garudathri, Jayanthi, Harrison, Joe J., Harwood, Rachel A., Penewit, Kelsi, Waalkes, Adam, Singh, Pradeep K., Salipante, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666152/
https://ncbi.nlm.nih.gov/pubmed/29089424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00517-17
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