Genomic Analysis Identifies Novel Pseudomonas aeruginosa Resistance Genes under Selection during Inhaled Aztreonam Therapy In Vivo

Inhaled aztreonam is increasingly used for chronic Pseudomonas aeruginosa suppression in patients with cystic fibrosis (CF), but the potential for that organism to evolve aztreonam resistance remains incompletely explored. Here, we performed genomic analysis of clonally related pre- and posttreatmen...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Autores principales: McLean, Kathryn, Lee, Duankun, Holmes, Elizabeth A., Penewit, Kelsi, Waalkes, Adam, Ren, Mingxin, Lee, Samuel A., Gasper, Joseph, Manoil, Colin, Salipante, Stephen J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2019
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709462/
https://ncbi.nlm.nih.gov/pubmed/31285231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00866-19
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