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Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes

There is growing interest in reversible and irreversible covalent inhibitors that target noncatalytic amino acids in target proteins. With a goal of targeting oncogenic K-Ras variants (e.g., G12D) by expanding the types of amino acids that can be targeted by covalent inhibitors, we survey a set of e...

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Detaylı Bibliyografya
Yayımlandı:Biochemistry
Asıl Yazarlar: McGregor, Lynn M., Jenkins, Meredith L., Kerwin, Caitlin, Burke, John E., Shokat, Kevan M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665167/
https://ncbi.nlm.nih.gov/pubmed/28621541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00271
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