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Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes
There is growing interest in reversible and irreversible covalent inhibitors that target noncatalytic amino acids in target proteins. With a goal of targeting oncogenic K-Ras variants (e.g., G12D) by expanding the types of amino acids that can be targeted by covalent inhibitors, we survey a set of e...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5665167/ https://ncbi.nlm.nih.gov/pubmed/28621541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00271 |
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