Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells

Myeloid-derived suppressor cells (MDSC) promote tumor growth by blocking anti-tumor T cell responses. Recent reports show that MDSC increase fatty acid uptake and fatty acid oxidation (FAO) to support their immunosuppressive functions. Inhibition of FAO promoted a therapeutic T cell-mediated anti-tu...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Al-Khami, Amir A., Zheng, Liqin, Del Valle, Luis, Hossain, Fokhrul, Wyczechowska, Dorota, Zabaleta, Jovanny, Sanchez, Maria D., Dean, Matthew J., Rodriguez, Paulo C., Ochoa, Augusto C.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665069/
https://ncbi.nlm.nih.gov/pubmed/29123954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1344804
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