Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma

Myeloid suppressor cells (MSCs) producing high levels of arginase I block T cell function by depleting l-arginine in cancer, chronic infections, and trauma patients. In cancer, MSCs infiltrating tumors and in circulation are an important mechanism for tumor evasion and impair the therapeutic potenti...

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Detalhes bibliográficos
Main Authors: Rodriguez, Paulo C., Hernandez, Claudia P., Quiceno, David, Dubinett, Steven M., Zabaleta, Jovanny, Ochoa, Juan B., Gilbert, Jill, Ochoa, Augusto C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213169/
https://ncbi.nlm.nih.gov/pubmed/16186186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050715
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