L-Arginine depletion blunts anti-tumor T cell responses by inducing myeloid-derived suppressor cells

Enzymatic depletion of the non-essential amino acid L-Arginine (L-Arg) in cancer patients by the administration of a pegylated form of the catabolic enzyme arginase I (peg-Arg I) has shown some promise as a therapeutic approach. However, L-Arg deprivation also suppresses T-cell responses in tumors....

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Fletcher, Matthew, Ramirez, Maria E., Sierra, Rosa A., Raber, Patrick, Thevenot, Paul, Al-Khami, Amir A., Sanchez-Pino, Dulfary, Hernandez, Claudia, Wyczechowska, Dorota D., Ochoa, Augusto C., Rodriguez, Paulo C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297565/
https://ncbi.nlm.nih.gov/pubmed/25406192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1491
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