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Laser-initiated Radical Trifluoromethylation of Peptides and Proteins and Its Application to Mass Spectrometry-Based Protein Footprinting

We describe a novel, laser-initiated radical trifluoromethylation for protein footprinting and establish its broad residue coverage. •CF(3) reacts with 18 of 20 common amino acids including Gly, Ala, Ser, Thr, Asp, Glu that are relatively “silent” with •OH. This new approach to footprinting is a bri...

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Pubblicato in:Angew Chem Int Ed Engl
Autori principali: Cheng, Ming, Zhang, Bojie, Cui, Weidong, Gross, Michael L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663992/
https://ncbi.nlm.nih.gov/pubmed/28901679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201706697
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