Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia

Maintenance of genome integrity via repair of DNA damage is a key biological process required to suppress diseases, including Fanconi anemia (FA). We generated loss-of-function human haploid cells for FA complementation group C (FANCC), a gene encoding a component of the FA core complex, and used ge...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Moder, Martin, Velimezi, Georgia, Owusu, Michel, Mazouzi, Abdelghani, Wiedner, Marc, Ferreira da Silva, Joana, Robinson-Garcia, Lydia, Schischlik, Fiorella, Slavkovsky, Rastislav, Kralovics, Robert, Schuster, Michael, Bock, Christoph, Ideker, Trey, Jackson, Stephen P., Menche, Jörg, Loizou, Joanna I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663702/
https://ncbi.nlm.nih.gov/pubmed/29089570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01439-x
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