Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48

Defects in DNA repair can cause various genetic diseases with severe pathological phenotypes. Fanconi anemia (FA) is a rare disease characterized by bone marrow failure, developmental abnormalities, and increased cancer risk that is caused by defective repair of DNA interstrand crosslinks (ICLs). He...

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Publicado no:Nat Commun
Main Authors: Velimezi, Georgia, Robinson-Garcia, Lydia, Muñoz-Martínez, Francisco, Wiegant, Wouter W., Ferreira da Silva, Joana, Owusu, Michel, Moder, Martin, Wiedner, Marc, Rosenthal, Sara Brin, Fisch, Kathleen M., Moffat, Jason, Menche, Jörg, van Attikum, Haico, Jackson, Stephen P., Loizou, Joanna I.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5996029/
https://ncbi.nlm.nih.gov/pubmed/29891926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04649-z
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