Mir-21 Mediates the Inhibitory Effect of Ang (1–7) on AngII-induced NLRP3 Inflammasome Activation by Targeting Spry1 in lung fibroblasts

MicroRNA-21 (mir-21) induced by angiotensin II (AngII) plays a vital role in the development of pulmonary fibrosis, and the NLRP3 inflammasome is known to be involved in fibrogenesis. However, whether there is a link between mir-21 and the NLRP3 inflammasome in pulmonary fibrosis is unknown. Angiote...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Sun, Na-Na, Yu, Chang-Hui, Pan, Miao-Xia, Zhang, Yue, Zheng, Bo-Jun, Yang, Qian-Jie, Zheng, Ze-Mao, Meng, Ying
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662719/
https://ncbi.nlm.nih.gov/pubmed/29084974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13305-3
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