miR-21 promotes NLRP3 inflammasome activation to mediate pyroptosis and endotoxic shock

miR-21 is aberrantly expressed, and plays a role in various types of tumors and many other diseases. However, the mechanism of miR-21 in LPS-induced septic shock is still unclear. In this study, we investigated the mechanism of miR-21 in LPS-induced pyroptosis and septic shock. Here, we show that mi...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Xue, Zhenyi, Xi, Qing, Liu, Hongkun, Guo, Xiangdong, Zhang, Jieyou, Zhang, Zimu, Li, Yan, Yang, Guangze, Zhou, Dongmei, Yang, Huiyun, Zhang, Lijuan, Zhang, Qi, Gu, Chao, Yang, Juhong, Da, Yurong, Yao, Zhi, Duo, Shuguang, Zhang, Rongxin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561921/
https://ncbi.nlm.nih.gov/pubmed/31189875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1713-z
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