MicroRNA-21 Mediates Angiotensin II-Induced Liver Fibrosis by Activating NLRP3 Inflammasome/IL-1β Axis via Targeting Smad7 and Spry1

Aims: Angiotensin II (AngII), a vasoconstrictive peptide of the renin–angiotensin system (RAS), promotes hepatic fibrogenesis and induces microRNA-21(mir-21) expression. Angiotensin-(1–7) [Ang-(1–7)] is a peptide of the RAS, which attenuates liver fibrosis. Recently, it was reported that the NOD-lik...

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Detalhes bibliográficos
Publicado no:Antioxid Redox Signal
Main Authors: Ning, Zuo-Wei, Luo, Xiao-Ying, Wang, Guo-Zhen, Li, Yang, Pan, Miao-Xia, Yang, Ren-Qiang, Ling, Xu-Guang, Huang, Shan, Ma, Xiao-Xin, Jin, Si-Yi, Wang, Dan, Li, Xu
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2017
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488354/
https://ncbi.nlm.nih.gov/pubmed/27502441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2016.6669
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