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A Novel Family of Small Molecules that Enhance the Intracellular Delivery and Pharmacological Effectiveness of Antisense and Splice Switching Oligonucleotides

The pharmacological effectiveness of oligonucleotides has been hampered by their tendency to remain entrapped in endosomes thus limiting their access to cytosolic or nuclear targets. We have previously reported a group of small molecules that enhance the effects of oligonucleotides by causing their...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Wang, Ling, Ariyarathna, Yamuna, Ming, Xin, Yang, Bing, James, Lindsey I., Kreda, Silvia M., Porter, Melissa, Janzen, William, Juliano, Rudolph L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662188/
https://ncbi.nlm.nih.gov/pubmed/28703575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00242
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