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Targeted Intracellular Delivery of Antisense Oligonucleotides Via Conjugation With Small Molecule Ligands

Selective delivery of antisense or siRNA oligonucleotides to cells and tissues via receptor-mediated endocytosis is becoming an important approach for oligonucleotide-based pharmacology. In most cases receptor targeting has been attained using antibodies or peptide-type ligands. Thus there are few e...

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Autori principali: Nakagawa, Osamu, Ming, Xin, Huang, Leaf, Juliano, Rudolph L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901626/
https://ncbi.nlm.nih.gov/pubmed/20550198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja102635c
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