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Covalent Conjugation of Oligonucleotides with Cell-Targeting Ligands

A continuing problem in the area of oligonucleotide-based therapeutics is the poor access of these molecules to their sites of action in the nucleus or cytosol. A number of approaches to this problem have emerged. One of the most interesting is the use of ligand-oligonucleotide conjugates to promote...

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Hlavní autoři: Alam, Md. Rowshon, Ming, Xin, Nakagawa, Osamu, Jin, Jian, Juliano, R.L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789861/
https://ncbi.nlm.nih.gov/pubmed/23777829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.05.037
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