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Conjugation with Receptor-Targeted Histidine-Rich Peptides Enhances the Pharmacological Effectiveness of Antisense Oligonucleotides

Ineffective delivery to intracellular sites of action is one of the key limitations to the use of antisense and siRNA oligonucleotides as therapeutic agents. Here, we describe molecular scale antisense oligonucleotide conjugates that bind selectively to a cell surface receptor, are internalized, and...

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Publicado en:Bioconjug Chem
Autores principales: Nakagawa, Osamu, Ming, Xin, Carver, Kyle, Juliano, Rudy
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4470295/
https://ncbi.nlm.nih.gov/pubmed/24354269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc400500h
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