Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity

Previous studies have reported that modification of histones alters aminoglycoside-induced hair cell death and hearing loss. In this study, we investigated three FDA-approved histone deacetylase (HDAC) inhibitors (vorinostat/SAHA, belinostat, and panobinostat) as protectants against aminoglycoside-i...

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Dettagli Bibliografici
Pubblicato in:Front Cell Neurosci
Autori principali: Yang, Chao-Hui, Liu, Zhiqi, Dong, Deanna, Schacht, Jochen, Arya, Dev, Sha, Su-Hua
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660723/
https://ncbi.nlm.nih.gov/pubmed/29114207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2017.00315
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