APOLs with low pH dependence can kill all African trypanosomes

The primate-specific serum protein apolipoprotein L1 (APOL1) is the only secreted member of a family of cell death promoting proteins1–4. APOL1 kills the bloodstream parasite Trypanosoma brucei brucei, but not the human sleeping sickness agents T.b. rhodesiense and T.b. gambiense3. We considered the...

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Publicado en:Nat Microbiol
Autores principales: Fontaine, Frédéric, Lecordier, Laurence, Vanwalleghem, Gilles, Uzureau, Pierrick, Van Reet, Nick, Fontaine, Martina, Tebabi, Patricia, Vanhollebeke, Benoit, Büscher, Philippe, Pérez-Morga, David, Pays, Etienne
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660622/
https://ncbi.nlm.nih.gov/pubmed/28924146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-017-0034-1
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