The K186E Amino Acid Substitution in the Canine Influenza Virus H3N8 NS1 Protein Restores Its Ability To Inhibit Host Gene Expression

Canine influenza viruses (CIVs) are the causative agents of canine influenza, a contagious respiratory disease in dogs, and include the equine-origin H3N8 and the avian-origin H3N2 viruses. Influenza A virus (IAV) nonstructural protein 1 (NS1) is a virulence factor essential for counteracting the in...

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Bibliographic Details
Published in:J Virol
Main Authors: Nogales, Aitor, Chauché, Caroline, DeDiego, Marta L., Topham, David J., Parrish, Colin R., Murcia, Pablo R., Martínez-Sobrido, Luis
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660486/
https://ncbi.nlm.nih.gov/pubmed/28835506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00877-17
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