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NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A Viruses

Influenza virus NS1 protein is a nonstructural, multifunctional protein that counteracts host innate immune responses, modulating virus pathogenesis. NS1 protein variability in subjects infected with H3N2 influenza A viruses (IAVs) during the 2010/2011 season was analyzed, and amino acid changes in...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Nogales, Aitor, Martinez-Sobrido, Luis, Topham, David J., DeDiego, Marta L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309952/
https://ncbi.nlm.nih.gov/pubmed/28003482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01930-16
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