Sitagliptin reduces inflammation, fibrosis and preserves diastolic function in a rat model of heart failure with preserved ejection fraction

BACKGROUND AND PURPOSE: Heart failure with preserved ejection fraction (HFpEF) is a systemic syndrome driven by co‐morbidities, and its pathophysiology is poorly understood. Several studies suggesting that dipeptidyl peptidase 4 (DPP4) might be involved in the pathophysiology of heart failure have p...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Esposito, Grazia, Cappetta, Donato, Russo, Rosa, Rivellino, Alessia, Ciuffreda, Loreta Pia, Roviezzo, Fiorentina, Piegari, Elena, Berrino, Liberato, Rossi, Francesco, De Angelis, Antonella, Urbanek, Konrad
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Themed Section: Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659996/
https://ncbi.nlm.nih.gov/pubmed/27922176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13686
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