Effects of ranolazine in a model of doxorubicin‐induced left ventricle diastolic dysfunction

BACKGROUND AND PURPOSE: Doxorubicin is a highly effective anticancer drug, but its clinical application is hampered by cardiotoxicity. Asymptomatic diastolic dysfunction can be the earliest manifestation of doxorubicin cardiotoxicity. Therefore, a search for therapeutic intervention that can interfe...

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Publicat a:Br J Pharmacol
Autors principals: Cappetta, Donato, Esposito, Grazia, Coppini, Raffaele, Piegari, Elena, Russo, Rosa, Ciuffreda, Loreta Pia, Rivellino, Alessia, Santini, Lorenzo, Rafaniello, Concetta, Scavone, Cristina, Rossi, Francesco, Berrino, Liberato, Urbanek, Konrad, De Angelis, Antonella
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Themed Section: Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647186/
https://ncbi.nlm.nih.gov/pubmed/28320043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13791
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