Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites

OBJECTIVE—: Atherosclerosis develops near branches and bends of arteries that are exposed to low shear stress (mechanical drag). These sites are characterized by excessive endothelial cell (EC) proliferation and inflammation that promote lesion initiation. The transcription factor HIF1α (hypoxia-ind...

詳細記述

保存先:
書誌詳細
出版年:Arterioscler Thromb Vasc Biol
主要な著者: Feng, Shuang, Bowden, Neil, Fragiadaki, Maria, Souilhol, Celine, Hsiao, Sarah, Mahmoud, Marwa, Allen, Scott, Pirri, Daniela, Ayllon, Blanca Tardajos, Akhtar, Shamima, Thompson, A.A. Roger, Jo, Hanjoong, Weber, Christian, Ridger, Victoria, Schober, Andreas, Evans, Paul C.
フォーマット: Artigo
言語:Inglês
出版事項: Lippincott Williams & Wilkins 2017
主題:
Basic Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659306/
https://ncbi.nlm.nih.gov/pubmed/28882872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.309249
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