Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites

OBJECTIVE—: Atherosclerosis develops near branches and bends of arteries that are exposed to low shear stress (mechanical drag). These sites are characterized by excessive endothelial cell (EC) proliferation and inflammation that promote lesion initiation. The transcription factor HIF1α (hypoxia-ind...

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Veröffentlicht in:Arterioscler Thromb Vasc Biol
Hauptverfasser: Feng, Shuang, Bowden, Neil, Fragiadaki, Maria, Souilhol, Celine, Hsiao, Sarah, Mahmoud, Marwa, Allen, Scott, Pirri, Daniela, Ayllon, Blanca Tardajos, Akhtar, Shamima, Thompson, A.A. Roger, Jo, Hanjoong, Weber, Christian, Ridger, Victoria, Schober, Andreas, Evans, Paul C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Lippincott Williams & Wilkins 2017
Schlagworte:
Basic Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659306/
https://ncbi.nlm.nih.gov/pubmed/28882872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.309249
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