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Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites
OBJECTIVE—: Atherosclerosis develops near branches and bends of arteries that are exposed to low shear stress (mechanical drag). These sites are characterized by excessive endothelial cell (EC) proliferation and inflammation that promote lesion initiation. The transcription factor HIF1α (hypoxia-ind...
Αποθηκεύτηκε σε:
Τόπος έκδοσης: | Arterioscler Thromb Vasc Biol |
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Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , |
Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
Lippincott Williams & Wilkins
2017
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5659306/ https://ncbi.nlm.nih.gov/pubmed/28882872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.309249 |
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