Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites

OBJECTIVE—: Atherosclerosis develops near branches and bends of arteries that are exposed to low shear stress (mechanical drag). These sites are characterized by excessive endothelial cell (EC) proliferation and inflammation that promote lesion initiation. The transcription factor HIF1α (hypoxia-ind...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Feng, Shuang, Bowden, Neil, Fragiadaki, Maria, Souilhol, Celine, Hsiao, Sarah, Mahmoud, Marwa, Allen, Scott, Pirri, Daniela, Ayllon, Blanca Tardajos, Akhtar, Shamima, Thompson, A.A. Roger, Jo, Hanjoong, Weber, Christian, Ridger, Victoria, Schober, Andreas, Evans, Paul C.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2017
Assuntos:
Basic Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659306/
https://ncbi.nlm.nih.gov/pubmed/28882872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.309249
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